David Goodlett
Professor, Biochemistry & Microbiology, University of Victoria
Dave is currently Professor of Biochemistry and Microbiology at the University of Victoria where he is also Director of the Genome BC Proteome Centre (https://www.proteincentre.com/). He is also a Mentor for the Chemical Biology group at the University of Gdansk’s International Centre for Cancer Vaccine Science (https://iccvs.ug.edu.pl/). Previously he was a Professor at the University of Maryland in Baltimore, MD (2013-2020). From 2012-2016 he was a Finland Distinguished Professor (FiDiPro) at the University of Turku in Turku, Finland. The research at the University of Turku was focused on discovery of serum protein markers that predict children who will develop type-1 diabetes prior to appearance of autoantibodies as well as cardiovascular disease in young Finns. More details of the FiDiPro projects are available here. From 2013 to 2016 Dave was the Isaac E. Emerson Professor of Pharmaceutical Sciences at the University of Maryland School of Pharmacy and from 2013-2015 he was Director of the UMB School of Pharmacy MS Center. From 2004-2012 he was Professor of Medicinal Chemistry at the University of Washington in Seattle, WA where he was also Director of the School of Pharmacy mass spectrometry facility.
His research includes hypothesis generating, discovery based efforts in protein and lipid A structure-function relationships in infectious organisms, proteomics technology development and informatics. Prior to his nine-year term at the University of Washington, he was Director of the Institute for Systems Biologyâ„¢ Proteomics laboratory (2000-2003). After postdoctoral work with Richard D. Smith at Pacific Northwest National Laboratory (1991-1993), he spent five years in the pharmaceutical industry and prior to that received his Ph.D. in 1991 with Richard B. van Breemen and Frank B. Armstrong (deceased) at North Carolina State University.
Originally, he was trained as a protein chemist at Auburn University with John Aull, Harlow Daron (deceased) and Frank Bartol. This training in structure-function relationships led to an eventual interest in the same concept for lipid A as it pertains to human health that he has investigated using mass spectrometry. His current efforts are supported by several burgeoning technology projects in mass spectrometry and microfluidics, as well as software development to support structure analysis and –omic pipelines. The discovery based science projects within the laboratory are used to generate hypotheses complementary to those generated by literature review in support of our medical and biological collaborators. In general, we take an indolent driven approach to experimentation that seeks parsimony in data acquisition and interpretation.Additionally, the structure-function relationships of lipid A as it pertains to human health have been investigated by my laboratory using mass spectrometry. All of these efforts are supported by several burgeoning technology projects in mass spectrometry and microfluidics, as well as software development to support structure analysis and –omic pipelines. The discovery based science projects within the laboratory are used to generate hypotheses complementary to those generated by literature review in support of our medical and biological collaborators. In general, we take an indolent driven approach to experimentation that seeks parsimony in data acquisition and interpretation.
His research includes hypothesis generating, discovery based efforts in protein and lipid A structure-function relationships in infectious organisms, proteomics technology development and informatics. Prior to his nine-year term at the University of Washington, he was Director of the Institute for Systems Biologyâ„¢ Proteomics laboratory (2000-2003). After postdoctoral work with Richard D. Smith at Pacific Northwest National Laboratory (1991-1993), he spent five years in the pharmaceutical industry and prior to that received his Ph.D. in 1991 with Richard B. van Breemen and Frank B. Armstrong (deceased) at North Carolina State University.
Originally, he was trained as a protein chemist at Auburn University with John Aull, Harlow Daron (deceased) and Frank Bartol. This training in structure-function relationships led to an eventual interest in the same concept for lipid A as it pertains to human health that he has investigated using mass spectrometry. His current efforts are supported by several burgeoning technology projects in mass spectrometry and microfluidics, as well as software development to support structure analysis and –omic pipelines. The discovery based science projects within the laboratory are used to generate hypotheses complementary to those generated by literature review in support of our medical and biological collaborators. In general, we take an indolent driven approach to experimentation that seeks parsimony in data acquisition and interpretation.Additionally, the structure-function relationships of lipid A as it pertains to human health have been investigated by my laboratory using mass spectrometry. All of these efforts are supported by several burgeoning technology projects in mass spectrometry and microfluidics, as well as software development to support structure analysis and –omic pipelines. The discovery based science projects within the laboratory are used to generate hypotheses complementary to those generated by literature review in support of our medical and biological collaborators. In general, we take an indolent driven approach to experimentation that seeks parsimony in data acquisition and interpretation.
phone: 250.721.7242
email: goodlett@uvic.ca
Helena Petrosova
Senior Scientist
Helena Petrosova, Ph.D., is a Group leader of a Mass spectrometry imaging unit at the UVic Genome BC Proteomics Center and an Adjunct assistant professor at the University of Victoria. Dr. Petrosova obtained her education at Masaryk University, Czech Republic. Her training comprised fellowships at the Institut Pasteur, Paris, France, and the University of Toronto.
email: helena@proteincentre.com
Abanoub Mikhael
Postdoctoral Fellow
Abanoub is a postdoctoral fellow at the UVic proteomics centre. He earned his Ph.D. in Analytical Chemistry at Memorial University of Newfoundland. His Ph.D. research focused on using tandem mass spectrometry to elucidate structure of complex biopolymers such as lignin and sporopollenin. Since joining the Goodlett lab in the summer of 2022, he developed methods to characterize bacterial lipopolysaccharides (LPS) and lipid A from different sources such as E. coli, P. aeruginosa and leptospira.
His research focused on using Field Asymmetric Ion Mobility tandem mass spectrometry (ESI-FAIMS-MS/MS) and Kendrick mass defect (KMD) plots to investigate LPS/lipid A structural variations between different bacterial strains. Additionally, He used ozone and laser induced dissociation (LID) to locate double bonds in the fatty acyl chains of Lipid A. The major purpose of his research is to understand the relationship between LPS/Lipid A chemical composition/structures and the bacterial virulence level and biological activity.
email: afmikhael@mun.ca
Madison Shiyuk
MSc student
Madison graduated from UVic with her BSc in Microbiology with Honours. She completed her honours research at the UVic Genome BC Proteomics Centre and is now continuing her work as a Master’s student. Her research focusses on using multiple modalities of mass spectrometry imaging to analyze several different classes of molecules within tissues.
email: mshiyuk@uvic.ca
Bo Ren
PhD Candidate
Bo graduated with MSc.in Biochemistry at the University of Edinburgh co-supervised by Javier. Bo's project revolved around the structural underpinnings of metabolite antigen presentation in MR-1. His project focussed on understanding how MR-1 could be leveraged for cancer immunotherapy by trying to understand which cancer metabolites in the aberrant metabolome could be presented to the immune system. He has a strong background in structural biology and computational metabolomics, as well as a certain understanding of drug discovery. Through the structural analysis of MR1 and its antigens, he successfully screened out some potential MR1 antigens in cancer cells. Currently, he is working on whole-cell proteomics analysis, and mainly focussed on MHC family and related peptides.
email: boren@uvic.ca
Linda Nartey
PhD Student
Linda graduated with a B.Sc. in Botany from the University of Ghana with her focus on fungal and bacterial contaminants in food and how they can be controlled. After her first degree, she worked at the Noguchi Memorial Institute for Medical Research where she had hands-on experience in diagnostic problems involved in determining the cause, control and drug discovery for Buruli ulcer as well as Schistosomiasis which is a known neglected tropical disease.
In 2018, she started her master’s degree in Microbiology at the Zhejiang Sci-Tech University under the supervision of Hu Xiu-fang focusing on the biological control of fungal phytopathogens. Her study reported the potential of Mucor moelleri isolated from the tea plant rhizosphere as a biological control agent on several fungal pathogens including Athelia rolfsii, Fusarium oxysporum, Glomerella cingulata, Colletotrichum gloeosporiodes, and Botrytis cinerea Pers.
Her current research is on microbial diagnostics using mass spectrometry imaging and proteomics.
email: lnartey@uvic.ca
Sophie Culos
MSc Student
Sophie was born and raised in the interior of BC as a settler on the traditional lands of the Okanagan and Shuswap people.
Sophie is in the final year of her BSc in Microbiology at Uvic. She joined the Goodlett Lab and adjoining Proteomics Centre as a co-op student, and is continuing on to complete her Honours thesis under Helena Petrosova. Her project is focused on characterizing lipid A of gram-negative Leptospira spirochetes and their resulting pathogenicity and adaptability.
Her free time is often devoted to playing games with friends, working on craft projects, and spending time near the ocean.
Kate McMurray
MSc Student
After graduating from UVic with a B.Sc in biochemistry Kate turned her co-op position at the UVic Genome BC Proteomics Centre into a full-time position. Working as a technician at the proteomics centre introduced Kate to the field of metabolomics and uncovered her interest in research. She is now a M.Sc student in the Goodlett lab working on the miniaturization of LC-MS based metabolomics assays. Kate hopes her miniaturized assays will allow for more efficient use of animal and patient derived samples while minimizing solvent and chemical waste produced by experiments.
email: kmcmurray@uvic.ca
Alex Panchaud
Associate R&D Specialist, Nestléesearch Center
Brendan Ribera
Unknown
My name is Brendan Ribera. I live in Seattle with my wife and kids, where we are members of Green Lake Presbyterian Church. I create software. I enjoy art, literature, music, startups, theology, hacking, baking, mathematics, open-source software, bicycling, backpacking, et cetera.
email: bredndan.ribera@gmail.com
Jace Jones
Laborator Research Manager, Department of Pharmaceutical Sciences UMB
email: jjones@rx.umaryland.edu
Jinzhi Chen
Takeda Pharmaceuticals (Research Associate)
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Sunhee Jung
Research Scientist III, Seattle Children's Research Institute
email: sunhee@u.washington.edu
Shivangi Awasthi
Graduate Student, Department of Pharmaceutical Sciences
phone: 410.706.3536
email: shivanngii@gmail.com
Will Fondrie
Postdoctoral Fellow
Will is now a postdoctoral fellow in Bill Noble's lab at the University of Washington Department of Genome Sciences.
email: wfondrie@uw.edu
Ashwini Selva
Lab Assistant
Mert Pekcan
Visiting Professor
Mert is a visiting scholar from Ankara University Faculty of Veterinary Medicine. His current research in Dr. David Goodlett’s lab is about identifying microbial pathogens in biological specimens at a short turnaround time without the need for cultures with MALDI-TOF mass spectrometry. The approach he will be using is called the Fast Lipid Analysis Technique (FLAT) and is developed by Professor Goodlett and his collaborators.
email: Mert.Pekcan@ankara.edu.tr
Kayleigh Morris
Honours thesis student
Kayleigh is in the last year of her undergraduate degree in Microbiology and is completing her honours research project. Her honours project will involve establishing a Matrix - Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI) platform for studying bacterial infections. Kayleigh has previous experience with histology after completing a Co-op at the Molecular and Cellular Immunology Core at the Deeley Research Centre in Victoria. She is interested in further studying immunology and human diseases after completing her bachelor's degree.
email: kayleighm@uvic.ca
Nasrin Hashemian
Visiting Graduate Student
Nasrin is a PhD student of Microbiology in Iran and came to the lab as a visiting student. Her thesis is focused on actinobacteria identification.
email: nhashemian86@gmail.com
Bruna Falgueras Vallbona
Visiting Student
Bruna is a part-time PhD student from the UK (NTU) and she came to the Goodlett lab as a visiting student. Her research is on studying uncertainty and the background noise of modern instrumentation to optimize their results.
Sha has been working with spectrophotometry instruments, and now she is moving on Mass Spectrometry.
She is joining the lab to have a better MS understanding to help her comprehend how to improve the underpinning statistics to be able to discern actual peaks from noise in the spectra.
Tanzila Rehman
Postdoctoral fellow
Tanzila is a Postdoctoral fellow at Genome BC Proteomics Centre.Her Postdoc project is establishing Matrix-assisted laser desorption/ionization Imaging mass spectrometry for studying the Metabolism of drugs. She has previous experience of studies on pesticides protein interactions involving Tandem Mass Spectrometry and MALDI-TOF at School of Pharmacy University of Maryland, USA. Tanzila is Assistant Professor of Biochemistry at Department of Chemistry, The Women University Multan, Pakistan.
email: tanzilarehman@uvic.ca
Jamine
honour
Alex Scherl
Univ. of Geneva Proteomics Core Facility and Biomedical Proteomics Research Group
email: Alexander.Scherl@unige.ch
Scott Edgar
Research Associate
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Yi-Hsuan (Shannon) Tsai
Graduate Student, BIological and Biomadeical Sciences, North Caolina
email: uo125000@gmail.com
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Thomas Schneider
Research Associate
University of Washington,
Department of Chemistry
Department of Chemistry
email: tschneid@uw.edu
Saddef Haq
Graduate Student
Alison Scott
Postdoctoral Fellow
Anuj Joshi
Postdoctoral Fellow
Anuj is a post-doctoral fellow with Professor David R Goodlett and the UVic Proteomics center at the University of Victoria, Canada. His current research focuses on microbial identification using MALDI-TOF mass spectrometry. The technique he uses is called Fast Lipid Analysis Technique (FLAT) and this technique is innovative, as it does not require recovery of bacteria by culture, simplifying the diagnosis of bacterial infections. His current work is in collaboration with Professor Robert Ernst at the University of Maryland and Pataigin which is a startup company that develops advanced microbiology tests to identify disease pathogens and determine antimicrobial resistance. His work is funded from Professor Goodlett`s R01 grant titled “MS Diagnostic Bacterial Identification Library†funded by NIH.
He finished his PhD under the supervision of Professor Scott McIndoe at the Department of Chemistry, University of Victoria. His PhD research focussed on studying Methylalumoxane by electrospray ionization mass spectrometry. Methylalumoxane is a widely used co-catalyst in olefin polymerization and despite its use for almost 50 years the structure and exact composition are unknown. His PhD work was partially funded by NOVA Chemicals’ Centre for Applied Research.
email: anujjoshi@uvic.ca
Kevin Gill
Research Volunteer
Kevin graduated with a Bachelors of Science in Computer Science in 2016 from the University of Victoria. He then went on to work as a Senior Software Developer in the music, hotel, rail transit, and higher education industries. He has experience working for startups, mid-sized companies, and enterprise organizations. He then switched career paths to start his MD in 2020 at the University of British Columbia’s Southern Medical Program in Kelowna.
Roseline Tran
Honours thesis student
Roseline is in the last year of her undergraduate degree in Microbiology pursuing an honours research project. Her project is on the detection of foodborne pathogens in leafy greens using Fast Lipid Analysis Technique and estimating the limit of detection with this protocol. She hopes to pursue graduate studies after the completion of her undergraduate degree. Her interests include proteomics and immunology.
email: Roselinet@uvic.ca
Conor maclean
Honours thesis student
Conor is a fourth-year biochemistry major at Uvic working on his honours thesis project studying Post-translational modifications of histone proteins in immune cells from cancer patients.
email: conor_maclean@hotmail.ca
Molly McCormack
Honours thesis student
Molly is in the last year of her undergraduate degree in Biochemistry. Her honours project will involve automating the Fast Lipid Analysis Technique (FLAT) to facilitate microbial diagnostics. Molly has previous experience in analytical chemistry through completing a co-op at an oil sands site in northern Alberta.
email: molly.a.mccormack@gmail.com
Stephanie Skalitzky
Honours Student
Stephanie was born in Switzerland and grew up in Austria and Germany. She is in her final year of obtaining her BSc in Biochemistry with a minor in Business at the University of Victoria. Her Honours thesis focuses on building a model of cancer cell expression of bacterial peptides, including using Orbitrap Fusion mass spectrometry to analyze bacterial-specific antigens to determine their source against the bacterial proteome.
Stephanie spent a year in Montreal as a co-op student working in R&D at Lallemand Biofuels and Distilled Spirits. A year later she returned to Montreal during the summer to work as an undergraduate research trainee in an interdisciplinary Biology lab at McGill University under Dr. Jackie Vogel.
email: sskalitzky@uvic.ca
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Jasmine
honour
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Chan Chun(Eric) Yong
Visiting Scholar, Associate Professor, Department of Pharmacy, University of Singapore
email: phaccye@nus.edu.sg
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Yu-Chieh (Philip) Kao
Visting Scientist
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Tanzila Rehman
Lecturer
The Women University Multan,
Department of Chemistry,
Pakistan
Department of Chemistry,
Pakistan
phone: 92.332.061.6379
email: bintehuwa35@hotmail.com
Robert K. Ernst
University of Maryland Dental School
phone: 410.706.2263
email: rkernst@umaryland.edu
Victor Ng
Institute of Biotechnology and Institute of Bioinformatics, National Yang Ming University
email: wvng@ym.edu.tw